Prothrombin thrombophilia is a clotting disorder involving increased risks for clots, venous thromboembolism (VTE), deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The gene responsible is F2, which encodes prothrombin. The common mutation is a G>A transition at nucleotide 20210A. Prothrombin thrombophilia is generally inherited in an autosomal dominant manner, however Homozygosity for the prothrombin gene mutation leads to a greater risk of clotting events.