Van der Woude syndrome is an autosomal dominant syndrome typically consisting of a cleft lip or cleft palate and distinctive pits of the lower lips. Although it is passed from parent to child, there is a range of possible symptoms in affected individuals. These variable signs include lip pits alone, absent teeth, or isolated cleft lip and palate of varying degrees of severity. Van der Woude syndrome can be caused by deletions in chromosome band 1q32. This disease affects about 1 in 100,000-200,000 people and about 1-2% of all individuals with cleft lip or palate.